Hyperviscosity in the newborn is defined as increased resistance to blood flow as a result of an abnormally high hematocrit (percentage of red blood cells in the whole blood) level.
Causes, incidence, and risk factors
Hyperviscosity results when the percentage of red blood cells (RBCs) in the infant's blood is greater than 65%. High hematocrits may result from various intrauterine conditions such as hypoxia , inherited diseases, and congenital abnormalities. The high percentage of RBCs causes blockage of blood flow in the smallest capillaries. This leads to tissue death from lack of oxygen. This blocked blood flow can affect all organs such as the kidneys, lungs, and brain. Infants with hyperviscosity may develop feeding problems, cyanosis , low blood sugar , elevated bilirubin ( jaundice ), and other more serious findings.
Signs and tests
CyanosisHypoglycemia ( low blood sugar )
Tachypnea ( rapid breathing )
Respiratory distress Renal failureJaundice Tests: CBC for hematocrit (percentage of RBCs/volume)
Chem-20 to check blood sugar, BUN , creatinine
Blood gasesUrinalysis
Expectations (prognosis)
The outcome is good in infants with mild hyperviscosity and in those with severe hyperviscosity that receive treatment.
Calling your health care provider
Call your health care provider if this condition is diagnosed at birth and you have additional questions.
Prevention
Newborn infants are routinely monitored for the hematocrit level, enabling quick detection of the condition.